CovidFranceV1, Main, Exploration, bibRecord, 000C88

Increased mortality in patients with severe SARS-CoV-2 infection admitted within seven days of disease onset.

Identifieur interne : 000C88 ( Main/Exploration ); précédent : 000C87; suivant : 000C89

Increased mortality in patients with severe SARS-CoV-2 infection admitted within seven days of disease onset.

Auteurs : Elie Azoulay [France] ; Muriel Fartoukh [France] ; Michael Darmon [France] ; Guillaume Géri [France] ; Guillaume Voiriot [France] ; Thibault Dupont [France] ; Lara Zafrani [France] ; Lola Girodias [France] ; Vincent Labbé [France] ; Martin Dres [France] ; Alexandra Beurton [France] ; Antoine Vieillard-Baron [France] ; Alexandre Demoule [France]

Source :

Intensive care medicine [ 1432-1238 ] ; 2020.

RBID : pubmed:32780165

Descripteurs français

KwdFr :
- Adulte d'âge moyen (MeSH), Betacoronavirus (MeSH), Comorbidité (MeSH), Délai jusqu'au traitement (MeSH), Facteurs de risque (MeSH), Facteurs temps (MeSH), Facteurs âges (MeSH), Femelle (MeSH), France (épidémiologie), Humains (MeSH), Infections à coronavirus (mortalité), Interleukine-6 (sang), Modèles des risques proportionnels (MeSH), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (mortalité), Réaction de polymérisation en chaine en temps réel (MeSH), Scores de dysfonction d'organes (MeSH), Troponine (sang), Unités de soins intensifs (statistiques et données numériques), Études rétrospectives (MeSH).
MESH :
- mortalité : Infections à coronavirus, Pneumopathie virale.
- sang : Interleukine-6, Troponine.
- statistiques et données numériques : Unités de soins intensifs.
- épidémiologie : France.
- Adulte d'âge moyen, Betacoronavirus, Comorbidité, Délai jusqu'au traitement, Facteurs de risque, Facteurs temps, Facteurs âges, Femelle, Humains, Modèles des risques proportionnels, Mâle, Pandémies, Réaction de polymérisation en chaine en temps réel, Scores de dysfonction d'organes, Études rétrospectives.
Wicri :
- geographic : France.

English descriptors

KwdEn :
- Age Factors (MeSH), Betacoronavirus (MeSH), Comorbidity (MeSH), Coronavirus Infections (mortality), Female (MeSH), France (epidemiology), Humans (MeSH), Intensive Care Units (statistics & numerical data), Interleukin-6 (blood), Male (MeSH), Middle Aged (MeSH), Organ Dysfunction Scores (MeSH), Pandemics (MeSH), Pneumonia, Viral (mortality), Proportional Hazards Models (MeSH), Real-Time Polymerase Chain Reaction (MeSH), Retrospective Studies (MeSH), Risk Factors (MeSH), Time Factors (MeSH), Time-to-Treatment (MeSH), Troponin (blood).
MESH :
- chemical , blood : Interleukin-6, Troponin.
- geographic , epidemiology : France.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- statistics & numerical data : Intensive Care Units.
- Age Factors, Betacoronavirus, Comorbidity, Female, Humans, Male, Middle Aged, Organ Dysfunction Scores, Pandemics, Proportional Hazards Models, Real-Time Polymerase Chain Reaction, Retrospective Studies, Risk Factors, Time Factors, Time-to-Treatment.

Abstract

PURPOSE

Coronavirus disease 2019 (COVID-19) is creating an unprecedented healthcare crisis. Understanding the determinants of mortality is crucial to optimise intensive care unit (ICU) resource use and to identify targets for improving survival.

METHODS

In a multicentre retrospective study, we included 379 COVID-19 patients admitted to four ICUs between 20 February and 24 April 2020 and categorised according to time from disease onset to ICU admission. A Cox proportional-hazards model identified factors associated with 28-day mortality.

RESULTS

Median age was 66 years (53-68) and 292 (77%) were men. The main comorbidities included obesity and overweight (67%), hypertension (49.6%) and diabetes (30.1%). Median time from disease onset (i.e., viral symptoms) to ICU admission was 8 (6-11) days (missing for three); 161 (42.5%) patients were admitted within a week of disease onset, 173 (45.6%) between 8 and 14 days, and 42 (11.1%) > 14 days after disease onset; day 28 mortality was 26.4% (22-31) and decreased as time from disease onset to ICU admission increased, from 37 to 21% and 12%, respectively. Patients admitted within the first week had higher SOFA scores, more often had thrombocytopenia or acute kidney injury, had more limited radiographic involvement, and had significantly higher blood IL-6 levels. Age, COPD, immunocompromised status, time from disease onset, troponin concentration, and acute kidney injury were independently associated with mortality.

CONCLUSION

The excess mortality in patients admitted within a week of disease onset reflected greater non-respiratory severity. Therapeutic interventions against SARS-CoV-2 might impact different clinical endpoints according to time since disease onset.

DOI: 10.1007/s00134-020-06202-3
PubMed: 32780165
PubMed Central: PMC7417780

Affiliations:

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Le document en format XML

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<author><name sortKey="Labbe, Vincent" sort="Labbe, Vincent" uniqKey="Labbe V" first="Vincent" last="Labbé">Vincent Labbé</name>
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<author><name sortKey="Beurton, Alexandra" sort="Beurton, Alexandra" uniqKey="Beurton A" first="Alexandra" last="Beurton">Alexandra Beurton</name>
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<author><name sortKey="Vieillard Baron, Antoine" sort="Vieillard Baron, Antoine" uniqKey="Vieillard Baron A" first="Antoine" last="Vieillard-Baron">Antoine Vieillard-Baron</name>
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<author><name sortKey="Geri, Guillaume" sort="Geri, Guillaume" uniqKey="Geri G" first="Guillaume" last="Géri">Guillaume Géri</name>
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<author><name sortKey="Voiriot, Guillaume" sort="Voiriot, Guillaume" uniqKey="Voiriot G" first="Guillaume" last="Voiriot">Guillaume Voiriot</name>
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<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive et Réanimation, Hôpital Tenon, APHP, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive et Réanimation, Hôpital Tenon, APHP, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dupont, Thibault" sort="Dupont, Thibault" uniqKey="Dupont T" first="Thibault" last="Dupont">Thibault Dupont</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive et Réanimation, Hôpital Saint-Louis, APHP, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Paris, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zafrani, Lara" sort="Zafrani, Lara" uniqKey="Zafrani L" first="Lara" last="Zafrani">Lara Zafrani</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive et Réanimation, Hôpital Saint-Louis, APHP, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive et Réanimation, Hôpital Saint-Louis, APHP, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Paris, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Girodias, Lola" sort="Girodias, Lola" uniqKey="Girodias L" first="Lola" last="Girodias">Lola Girodias</name>
<affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Paris, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive et Réanimation, Hôpital Ambroise Paré, APHP, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive et Réanimation, Hôpital Ambroise Paré, APHP, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Labbe, Vincent" sort="Labbe, Vincent" uniqKey="Labbe V" first="Vincent" last="Labbé">Vincent Labbé</name>
<affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Paris, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive et Réanimation, Hôpital Tenon, APHP, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive et Réanimation, Hôpital Tenon, APHP, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dres, Martin" sort="Dres, Martin" uniqKey="Dres M" first="Martin" last="Dres">Martin Dres</name>
<affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Paris, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive et Réanimation, Hôpital Pitié-Salpêtrière, APHP, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive et Réanimation, Hôpital Pitié-Salpêtrière, APHP, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beurton, Alexandra" sort="Beurton, Alexandra" uniqKey="Beurton A" first="Alexandra" last="Beurton">Alexandra Beurton</name>
<affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Paris, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive et Réanimation, Hôpital Pitié-Salpêtrière, APHP, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive et Réanimation, Hôpital Pitié-Salpêtrière, APHP, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vieillard Baron, Antoine" sort="Vieillard Baron, Antoine" uniqKey="Vieillard Baron A" first="Antoine" last="Vieillard-Baron">Antoine Vieillard-Baron</name>
<affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Paris, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive et Réanimation, Hôpital Ambroise Paré, APHP, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive et Réanimation, Hôpital Ambroise Paré, APHP, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Demoule, Alexandre" sort="Demoule, Alexandre" uniqKey="Demoule A" first="Alexandre" last="Demoule">Alexandre Demoule</name>
<affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Paris, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive et Réanimation, Hôpital Pitié-Salpêtrière, APHP, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive et Réanimation, Hôpital Pitié-Salpêtrière, APHP, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Intensive care medicine</title>
<idno type="eISSN">1432-1238</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Comorbidity (MeSH)</term>
<term>Coronavirus Infections (mortality)</term>
<term>Female (MeSH)</term>
<term>France (epidemiology)</term>
<term>Humans (MeSH)</term>
<term>Intensive Care Units (statistics & numerical data)</term>
<term>Interleukin-6 (blood)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Organ Dysfunction Scores (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (mortality)</term>
<term>Proportional Hazards Models (MeSH)</term>
<term>Real-Time Polymerase Chain Reaction (MeSH)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Risk Factors (MeSH)</term>
<term>Time Factors (MeSH)</term>
<term>Time-to-Treatment (MeSH)</term>
<term>Troponin (blood)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Comorbidité (MeSH)</term>
<term>Délai jusqu'au traitement (MeSH)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Facteurs temps (MeSH)</term>
<term>Facteurs âges (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>France (épidémiologie)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (mortalité)</term>
<term>Interleukine-6 (sang)</term>
<term>Modèles des risques proportionnels (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (mortalité)</term>
<term>Réaction de polymérisation en chaine en temps réel (MeSH)</term>
<term>Scores de dysfonction d'organes (MeSH)</term>
<term>Troponine (sang)</term>
<term>Unités de soins intensifs (statistiques et données numériques)</term>
<term>Études rétrospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Interleukin-6</term>
<term>Troponin</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>France</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Interleukine-6</term>
<term>Troponine</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Intensive Care Units</term>
</keywords>
<keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Unités de soins intensifs</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>France</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Age Factors</term>
<term>Betacoronavirus</term>
<term>Comorbidity</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Organ Dysfunction Scores</term>
<term>Pandemics</term>
<term>Proportional Hazards Models</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Retrospective Studies</term>
<term>Risk Factors</term>
<term>Time Factors</term>
<term>Time-to-Treatment</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Betacoronavirus</term>
<term>Comorbidité</term>
<term>Délai jusqu'au traitement</term>
<term>Facteurs de risque</term>
<term>Facteurs temps</term>
<term>Facteurs âges</term>
<term>Femelle</term>
<term>Humains</term>
<term>Modèles des risques proportionnels</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>Scores de dysfonction d'organes</term>
<term>Études rétrospectives</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>PURPOSE</b>
</p>
<p>Coronavirus disease 2019 (COVID-19) is creating an unprecedented healthcare crisis. Understanding the determinants of mortality is crucial to optimise intensive care unit (ICU) resource use and to identify targets for improving survival.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>In a multicentre retrospective study, we included 379 COVID-19 patients admitted to four ICUs between 20 February and 24 April 2020 and categorised according to time from disease onset to ICU admission. A Cox proportional-hazards model identified factors associated with 28-day mortality.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Median age was 66 years (53-68) and 292 (77%) were men. The main comorbidities included obesity and overweight (67%), hypertension (49.6%) and diabetes (30.1%). Median time from disease onset (i.e., viral symptoms) to ICU admission was 8 (6-11) days (missing for three); 161 (42.5%) patients were admitted within a week of disease onset, 173 (45.6%) between 8 and 14 days, and 42 (11.1%) > 14 days after disease onset; day 28 mortality was 26.4% (22-31) and decreased as time from disease onset to ICU admission increased, from 37 to 21% and 12%, respectively. Patients admitted within the first week had higher SOFA scores, more often had thrombocytopenia or acute kidney injury, had more limited radiographic involvement, and had significantly higher blood IL-6 levels. Age, COPD, immunocompromised status, time from disease onset, troponin concentration, and acute kidney injury were independently associated with mortality.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>The excess mortality in patients admitted within a week of disease onset reflected greater non-respiratory severity. Therapeutic interventions against SARS-CoV-2 might impact different clinical endpoints according to time since disease onset.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32780165</PMID>
<DateCompleted><Year>2020</Year>
<Month>09</Month>
<Day>17</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>17</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-1238</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>46</Volume>
<Issue>9</Issue>
<PubDate><Year>2020</Year>
<Month>Sep</Month>
</PubDate>
</JournalIssue>
<Title>Intensive care medicine</Title>
<ISOAbbreviation>Intensive Care Med</ISOAbbreviation>
</Journal>
<ArticleTitle>Increased mortality in patients with severe SARS-CoV-2 infection admitted within seven days of disease onset.</ArticleTitle>
<Pagination><MedlinePgn>1714-1722</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s00134-020-06202-3</ELocationID>
<Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">Coronavirus disease 2019 (COVID-19) is creating an unprecedented healthcare crisis. Understanding the determinants of mortality is crucial to optimise intensive care unit (ICU) resource use and to identify targets for improving survival.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">In a multicentre retrospective study, we included 379 COVID-19 patients admitted to four ICUs between 20 February and 24 April 2020 and categorised according to time from disease onset to ICU admission. A Cox proportional-hazards model identified factors associated with 28-day mortality.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Median age was 66 years (53-68) and 292 (77%) were men. The main comorbidities included obesity and overweight (67%), hypertension (49.6%) and diabetes (30.1%). Median time from disease onset (i.e., viral symptoms) to ICU admission was 8 (6-11) days (missing for three); 161 (42.5%) patients were admitted within a week of disease onset, 173 (45.6%) between 8 and 14 days, and 42 (11.1%) > 14 days after disease onset; day 28 mortality was 26.4% (22-31) and decreased as time from disease onset to ICU admission increased, from 37 to 21% and 12%, respectively. Patients admitted within the first week had higher SOFA scores, more often had thrombocytopenia or acute kidney injury, had more limited radiographic involvement, and had significantly higher blood IL-6 levels. Age, COPD, immunocompromised status, time from disease onset, troponin concentration, and acute kidney injury were independently associated with mortality.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The excess mortality in patients admitted within a week of disease onset reflected greater non-respiratory severity. Therapeutic interventions against SARS-CoV-2 might impact different clinical endpoints according to time since disease onset.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Azoulay</LastName>
<ForeName>Elie</ForeName>
<Initials>E</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-8162-1508</Identifier>
<AffiliationInfo><Affiliation>Service de Médecine Intensive et Réanimation, Hôpital Saint-Louis, APHP, Paris, France. elie.azoulay@aphp.fr.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université de Paris, Paris, France. elie.azoulay@aphp.fr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fartoukh</LastName>
<ForeName>Muriel</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Université de Paris, Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service de Médecine Intensive et Réanimation, Hôpital Tenon, APHP, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Darmon</LastName>
<ForeName>Michael</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Service de Médecine Intensive et Réanimation, Hôpital Saint-Louis, APHP, Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université de Paris, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Géri</LastName>
<ForeName>Guillaume</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Université de Paris, Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service de Médecine Intensive et Réanimation, Hôpital Ambroise Paré, APHP, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Voiriot</LastName>
<ForeName>Guillaume</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Université de Paris, Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service de Médecine Intensive et Réanimation, Hôpital Tenon, APHP, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dupont</LastName>
<ForeName>Thibault</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Service de Médecine Intensive et Réanimation, Hôpital Saint-Louis, APHP, Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université de Paris, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zafrani</LastName>
<ForeName>Lara</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Service de Médecine Intensive et Réanimation, Hôpital Saint-Louis, APHP, Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université de Paris, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Girodias</LastName>
<ForeName>Lola</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Université de Paris, Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service de Médecine Intensive et Réanimation, Hôpital Ambroise Paré, APHP, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Labbé</LastName>
<ForeName>Vincent</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Université de Paris, Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service de Médecine Intensive et Réanimation, Hôpital Tenon, APHP, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dres</LastName>
<ForeName>Martin</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Université de Paris, Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service de Médecine Intensive et Réanimation, Hôpital Pitié-Salpêtrière, APHP, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Beurton</LastName>
<ForeName>Alexandra</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Université de Paris, Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service de Médecine Intensive et Réanimation, Hôpital Pitié-Salpêtrière, APHP, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vieillard-Baron</LastName>
<ForeName>Antoine</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Université de Paris, Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service de Médecine Intensive et Réanimation, Hôpital Ambroise Paré, APHP, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Demoule</LastName>
<ForeName>Alexandre</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Université de Paris, Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service de Médecine Intensive et Réanimation, Hôpital Pitié-Salpêtrière, APHP, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D064888">Observational Study</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>08</Month>
<Day>11</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Intensive Care Med</MedlineTA>
<NlmUniqueID>7704851</NlmUniqueID>
<ISSNLinking>0342-4642</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014336">Troponin</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
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<CitationSubset>IM</CitationSubset>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
</MeshHeading>
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<Reference><Citation>Cytokine Growth Factor Rev. 2020 Jun;53:38-42</Citation>
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<Reference><Citation>JAMA. 2020 Feb 7;:</Citation>
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<Reference><Citation>Nature. 2020 Mar;579(7798):265-269</Citation>
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   |wiki=    Sante
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   |texte=   Increased mortality in patients with severe SARS-CoV-2 infection admitted within seven days of disease onset.
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	Serveur d'exploration sur la COVID en France
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Increased mortality in patients with severe SARS-CoV-2 infection admitted within seven days of disease onset.

Increased mortality in patients with severe SARS-CoV-2 infection admitted within seven days of disease onset.

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